Incidence and outcomes of cancer in 16- to 17-year-old adolescents.
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ABSTRACT:
SUBMITTER: Ventela J
PROVIDER: S-EPMC9299452 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Incidence and outcomes of cancer in 16- to 17-year-old adolescents.
Ventelä Julia J Nikkilä Atte A Jukkola Arja A Lohi Olli O
Acta paediatrica (Oslo, Norway : 1992) 20211111 2
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Project description:BackgroundHair has become an increasingly valuable medium to investigate the association between chronic stress, stable differences in systemic cortisol secretion and later health. Assessing cortisol in hair has many advantages, notably its non-invasive and retrospective nature, the need for a single biospecimen and convenient storage until analysis. However, few studies offered empirical evidence documenting the long-term temporal stability of hair cortisol concentration (HCC) prior to analysis, especially in humans. Yet, knowing how long hair samples can be stored without compromising the accuracy of cortisol measurement is of crucial importance when planning data collection and analysis. This study examined the stability of HCC in hair samples assayed twice, five years apart.MethodsWe randomly selected from a larger distribution of HCC measured in 17-year-old participants 39 hair samples to be reanalyzed five years later, under the same general conditions. Samples were assayed in duplicate using a luminescence immunoassay and compared with the original HCC using the Lin's concordance correlation coefficient (CCC), Bland-Altman plot analysis and Wilcoxon rank test.ResultsFindings indicated a good concordance and temporal stability between the two samples assayed five years apart (CCC [95% confidence interval] = 0.84 [0.72-0.91]), although a small decrease in HCC was noted 5 years later (8.4% reduction, p = 0.001).ConclusionOur study confirms that hair samples, when stored at room temperature and away from sunlight, can be assayed for at least five years without risking a loss of precision in HCC measurement.
| S-EPMC11039327 | biostudies-literature
Project description:BackgroundThe uncertain and challenging situation caused by the COVID-19 pandemic affects adolescents and their parents in an exceptional way. More knowledge of health-related quality of life (HRQoL), health literacy (HL) and COVID-19-related worries in adolescents and parents 1 year into the pandemic is needed. The present study aimed to describe HRQoL, HL and COVID-19-related worries of 16- to 17-year-old adolescents and parents of adolescents. Further, to assess the strength of associations between gender, HL, COVID-19-related worries and HRQoL.MethodsA cross-sectional study involving 215 adolescents and 320 parents was conducted, exploring HRQoL, HL, COVID-19-related worries and sociodemographic variables. KIDSCREEN-10 and RAND-36 were used to measure HRQoL. Data were analyzed using bivariate methods, multiple linear regression and robust regression.ResultsAdolescents' HRQoL was notably lower compared to previous Norwegian studies and European norms. Parents' HRQoL was comparable to Norwegian norms. Adolescents and parents reported moderate-to-high HL and high degrees of COVID-19-related worries. Females reported significantly lower HRQoL and more worries compared to males. In adolescents, higher HL was significantly associated with higher HRQoL. COVID-19-related worries were not significantly associated with HRQoL. In parents, higher HL in the "understand health information" domain was significantly associated with higher HRQoL for mental well-being (mental component sum scores [MCS]) and with lower HRQoL for physical well-being (physical component sum scores [PCS]). Being worried a lot about infecting others and about family/friends becoming sick was significantly associated with higher MCS and lower MCS, respectively. COVID-19-related worries were not significantly associated with PCS.ConclusionsOur results indicate that the pandemic has a major negative impact on adolescents' HRQoL. Parents' HRQoL remained unchanged and comparable to previous studies. Our study demonstrates that HL, gender and COVID-19-related worries are significantly associated with adolescents' and parents' HRQoL, indicating that efforts aimed at increasing their HL might indirectly affect their HRQoL as well and that gender-specific interventions or strategies could be beneficial.
| S-EPMC9271239 | biostudies-literature
Project description:The traditional concept of education and school settings significantly contribute to the sedentary behavior of adolescents at secondary schools. The aim of this study is to identify the volume and intensity of physical activity (PA) that adolescent boys and girls engage in during recesses, after school, and during the day to compensate for sedentary behavior in lessons. The study was conducted at 29 Czech and 9 Polish schools. The study involved 868 girls and 409 boys aged 15-17 years. An ActiTrainerTM accelerometer was used to monitor PA and heart rate. Participants were divided into four quartile groups. Most sedentary boys and girls had less PA and showed a worse ratio of physical inactivity (PI)/PA than non-sedentary participants during recesses. In the after-school period, there were no significant differences. On school days, most sedentary boys and girls showed lower PA, a worse ratio of PI/PA, fewer steps·hour-1, and lower energy expenditure than their non-sedentary counterparts. Vigorous PA of ?8 METs was reached by 48% of most sedentary boys (75% non-sedentary) and 47% of most sedentary girls (54% non-sedentary). Most sedentary adolescents do not compensate for their sedentary behavior in lessons with higher PA intensity or volume during recesses, after-school, or in overall daily PA.
| S-EPMC7246541 | biostudies-literature
Project description:Harmful drinking among young people is common in Australia and many other countries. Social norms and their influence on adolescents' alcohol consumption behaviours have received much research attention in recent years. However, there is limited understanding of how social norms related to alcohol are developed and transmitted across social networks and a specific tool that measures these constructs has yet to be developed. This paper outlines the rationale and protocol for the design and validation of a multidimensional survey instrument which measures the development and transmission pathways of alcohol-related norms among adolescents. A longer term aim is to apply the instrument in a respondent-driven sampling study with a large adolescent cohort.Social Cognitive Theory (SCT) and relevant literature will guide the design of the online survey instrument. Feedback from a practitioner-based stakeholder committee, academic expert panel reviews, focus groups and interviews with adolescents aged 13-17 years in Perth, Western Australia (WA) will serve to ascertain content and face validity. A test-retest will be conducted using a purposive sample of students (n=400) at secondary schools in Perth. The instrument's psychometric properties will be analysed, including exploratory factor analyses, discriminant validity, internal consistency and test-retest reliability.The results of this research will provide public health researchers and practitioners with a comprehensive standardised instrument to explore the characteristics of individual-level and community-level social influences and norms associated with use of alcohol by adolescents and the routes through which these norms are transmitted. The data collected by the instrument is anticipated to inform the design of youth specific interventions with the potential to reduce alcohol-related harms. The Study findings will be disseminated widely through peer-reviewed publications and conference presentations. The study has received approval from the Curtin University Human Research Ethics Committee.
| S-EPMC3753520 | biostudies-other
Project description:Although gastroesophageal reflux disease (GERD) is common in adolescents, the burden of GERD on health-related quality of life (HRQOL) in adolescents has not been previously evaluated. Therefore, the objective of the study was to examine the effect of GERD on HRQOL in adolescents.This international, 31-site, 8-week safety study randomized adolescents, aged 12 to 17 years inclusive, with GERD to receive esomeprazole 20 or 40 mg once daily. The Quality of Life in Reflux and Dyspepsia questionnaire (QOLRAD), previously validated in adults, consists of 25 questions grouped into 5 domains: emotional distress, sleep disturbance, food/drink problems, physical/social functioning, and vitality. The QOLRAD was administered at the baseline and week-8 (final) visits.Of the 149 patients randomized, 134 completed the QOLRAD at baseline and final visits and were eligible for analysis of their HRQOL data. Baseline QOLRAD scores indicated GERD had a negative effect on the HRQOL of these adolescents, especially in the domains of vitality and emotional distress, and problems with food/drink. At the final visit, mean scores for all 5 QOLRAD domains improved significantly (P < .0001); change of scores (ie, delta) for all domains met or exceeded the adult QOLRAD minimal clinically significant difference standard of 0.5 units.GERD had a negative effect on QOL in adolescents. After esomeprazole treatment, statistically and clinically significant improvements occurred in all domains of the QOLRAD for these adolescents.D9614C00098; ClinicalTrials.gov Identifier NCT00241501.
| S-EPMC2784471 | biostudies-literature
Project description:The purpose of this study was to examine polygenic profiles previously associated with maturity timing in male academy football players across different age phases. Thus, 159 male football players from four English academies (U12-16, n = 86, aged 13.58 ± 1.58 years; U17-23, n = 73, aged 18.07 ± 1.69 years) and 240 male European controls were examined. Polygenic profiles comprised 39 single nucleotide polymorphisms and were analysed using unweighted and weighted total genotype scores (TGSs; TWGSs). There were significant differences in polygenic profiles between groups, whereby U17-23 players had more genetic variants associated with later maturity compared to U12-16 players (TGS, p = 0.010; TWGS, p = 0.024) and controls (TGS, p = 0.038; TWGS, p = 0.020). More specifically, U17-23 players had over two-times the odds of possessing >36 later-maturing alleles than <30 compared to U12-16 players (odds ratio (OR) = 2.84) and controls (OR = 2.08). These results suggest there was a greater proportion of relatively later-maturing players as maturation plateaus towards adulthood, which may be explained by the 'underdog hypothesis'. This study provides the first known molecular evidence that supports the notion that a maturity selection bias exists within male academy football.
| S-EPMC10380058 | biostudies-literature
Project description:BackgroundThe widespread ownership of digital devices among adolescents presents challenges and opportunities in schools, particularly during recess. This study aimed to examine the association of screen use during recess with physical activity behaviours.MethodsThe study was based on a population-based cross-sectional study including 1347 adolescents from 28 schools (2017-2018). Physical activity behaviours were assessed using thigh-attached accelerometers, worn 24/7 for up to 6 weekdays and 2 weekend days. We examined accelerometer data for all recess periods, aligned with each adolescent's school schedule, along with leisure-time activity from the same days. Physical behaviours were classified during recess and leisure-time behaviour (negative control). Frequency of screen use during recess was based on self-report using a 5-point ordinal scale.ResultsGreater frequency of screen use during recess was associated with less time engaged in physically active behaviours and more time spent sitting, consistent with dose-dependent associations. In multivariable-adjusted analysis, adolescents with no screen use during recess spent an absolute 11.1% (95% CI 5.4 to 6.8) more of their recess time being physically active compared to those with frequent use. Based on the mean recess duration observed in the sample, adolescents not using screens during recess engaged in physical activities for an average of 44.9 min per day (95% CI 42.3 to 47.6), compared with 35.1 min (95% CI 26.0 to 44.3) for frequent screen users. Leisure time activities, used as a negative control, showed no link to screen use during recess.ConclusionIncreased screen use during recess was associated with lower physical activity levels. These findings suggest that regulating digital device use during recess could enhance physical activity among adolescents.
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Project description:BackgroundSince children can only control and limit their own media use to a limited extent, it is often the parents who regulate their children's media use. However, there is insufficient research on which strategies they use and on how these strategies are related to socio-demographic and behavioral parameters.MethodsThe parental media regulation strategies co-use, active mediation, restrictive mediation, monitoring, and technical mediation were assessed in a sample of 563 four- to 16-year-old children and adolescents from middle to high social strata participating in the German cohort study LIFE Child. We investigated cross-sectional associations with socio-demographic characteristics (age and sex of child, age of parent, and socio-economic status (SES)) and other behavioral parameters of children (media use, ownership of media devices, engagement in extracurricular activities) and their parents (media use).ResultsAll media regulation strategies were applied frequently, with restrictive mediation occurring most frequently. Overall, parents of younger children and of boys mediated media use more frequently, while we observed no differences depending on SES. Regarding child behavior, the ownership of a smartphone and a tablet/personal computer/laptop was associated with more frequent technical restriction, while screen time and engagement in extracurricular activities was not associated with parental media regulation. In contrast, parental screen time was related to more frequent co-use and less frequent use of restrictive and technical mediation.ConclusionParental regulation of child media use is influenced by parental attitudes and a perceived need for mediation (e.g., in younger children or children owning internet-enabled devices) rather than child behavior.
| S-EPMC9942333 | biostudies-literature
Project description:BackgroundFactors that influence unhealthy behaviours in adolescents may have different impacts in different sociocultural settings. There is lack of research on the association between psychosocial vulnerability and unhealthy behaviours in adolescents, particularly outside the United States. The aim was to investigate both direct and indirect relationships between psychosocial conditions (subjective well-being, social relationships and self-esteem) and four health-related behaviours (smoking, alcohol consumption, meal frequency and physical activity) in Swedish adolescents aged 15-16 years. Socio-demographic variables (socio-economic status, gender and age) were also investigated.MethodsTo study these associations, a hypothesised model was tested using structural equation modelling. In the hypothesised model, interrelated psychosocial conditions (low well-being, poor social relationships and low self-esteem) and socio-demographic factors (low self-perceived socio-economic status, being female and higher age) together represented a vulnerability underlying smoking, alcohol consumption, irregular meal frequency and low level of physical activity. In this cross-sectional study, self-report questionnaires were used to collect data from 492 adolescents.ResultsHypothesised pathways between psychosocial conditions, socio-demographic factors and the four unhealthy behaviours were confirmed. Low well-being was strongly associated with unhealthy behaviours, and poor social relationships showed a strong indirect association with the unhealthy behaviours. Low self-esteem, low self-perceived socio-economic status and female gender were also vulnerability factors for the unhealthy behaviours.ConclusionsVulnerability for four common unhealthy behaviours was found in Swedish adolescents. This study presents the interrelationships of psychosocial and socio-demographic factors and how they were related with unhealthy behaviours. The results bring new insight into how psychosocial factors are related to unhealthy behaviours in adolescents living in northern Europe.
| S-EPMC5732431 | biostudies-literature
Project description:BackgroundSchools have a crucial role to play in preventing youth smoking. However, the well-known long-term health consequences of youth smoking may be insufficient to convince education stakeholders to devote efforts to implement school-based programmes. However, if youth smoking were to have short-term consequences, this evidence could prompt education stakeholders' action. In this article, we investigate the link between smoking and school absenteeism.MethodsWe used data from the 2011 wave of the European School Survey Project on Alcohol and Other Drugs, on adolescents aged 15-16. We applied logistic models to assess the risk of more than 3 missed school days, by cause, as function of smoking intensity, adjusting for age, sex, socioeconomic status, academic performance, parental involvement and other risk behaviours (alcohol and cannabis consumption). Consistency was assessed by replicating the analyses for each sex and age group and further adjusting for depression and self-esteem.ResultsSmoking more than five cigarettes per day was significantly linked to school absenteeism, with a 55% excess risk of missing more than 3 school days per month due to illness (OR = 1.55, 95% CI 1.46-1.64), and a more than two times excess risk due to skipping (OR = 2.29; 95% CI 2.16-2.43). These findings were consistent across age and sex groups.ConclusionWe observed an association between smoking intensity and absenteeism among youth in Europe. This implies that, to the extent that this association is causal, school tobacco control policies may reduce the short-term consequences of smoking on adolescents' education and health.
| S-EPMC6660109 | biostudies-literature