Insulin induces a progressive increase in the resistance of subcutaneous tissue to fluid flow: Implications for insulin pump therapy.

ABSTRACT:

Aim

To determine the effect of insulin on the resistance of subcutaneous tissue to the flow of infusion fluids.

Materials and methods

Thirty subjects with type 1 diabetes wore two Accu-Chek Spirit Combo insulin pumps with Accu-Chek FlexLink infusion sets (Roche Diabetes Care, Mannheim, Germany) for 7 days. One pump was filled with insulin aspart (Novo Nordisk, Bagsvaerd, Denmark) and used for continuous subcutaneous insulin infusion (CSII). The other pump was filled with insulin diluting medium (IDM; Novo Nordisk) and used to deliver IDM subcutaneously at rates identical to those employed for CSII. Both infusion sites were assessed daily by measuring the pressure required to infuse various bolus amounts of IDM.

Results

On day 1, maximum pressure (P_max ) and

SUBMITTER: Regittnig W 

PROVIDER: S-EPMC9299465 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature