Partial Tendon Injury at the Tendon-to-Bone Enthesis Activates Skeletal Stem Cells.

ABSTRACT: The tendon enthesis plays a critical role in facilitating movement and reducing stress within joints. Partial enthesis injuries heal in a mechanically inferior manner and never achieve healthy tissue function. The cells responsible for tendon-to-bone healing remain incompletely characterized and their origin is unknown. Here, we evaluated the putative role of mouse skeletal stem cells (mSSCs) in the enthesis after partial-injury. We found that mSSCs were present at elevated levels within the enthesis following injury and that these cells downregulated TGFβ signaling pathway elements at both the RNA and protein levels. Exogenous application of TGFβ post-injury led to a reduced mSSC response and impaired healing, whereas treatment with a TGFβ inhibitor (SB43154) resulted in a more robust mSS

SUBMITTER: Titan AL 

PROVIDER: S-EPMC9299518 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature