Multiepitope supramolecular peptide nanofibers eliciting coordinated humoral and cellular antitumor immune responses.

ABSTRACT: Subunit vaccines inducing antibodies against tumor-specific antigens have yet to be clinically successful. Here, we use a supramolecular α-helical peptide nanofiber approach to design epitope-specific vaccines raising simultaneous B cell, CD8⁺ T cell, and CD4⁺ T cell responses against combinations of selected epitopes and show that the concurrent induction of these responses generates strong antitumor effects in mice, with significant improvements over antibody or CD8⁺ T cell-based vaccines alone, in both prophylactic and therapeutic subcutaneous melanoma models. Nanofiber vaccine-induced antibodies mediated in vitro tumoricidal antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). The addition of immune checkp

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9299545 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature