Correlated functional connectivity and glucose metabolism in brain white matter revealed by simultaneous MRI/positron emission tomography.

ABSTRACT:

Purpose

There has been converging evidence of reliable detections of blood oxygenation level dependent (BOLD) signals evoked by neural stimulation and in a resting state in white matter (WM), within which few studies examined the relationship between BOLD functional signals and tissue metabolism. The purpose of the present study was to explore whether such relationship exists using combined functional MRI and positron emission tomography (PET) measurements of glucose uptake.

Methods

Functional and metabolic imaging data from 25 right-handed healthy human adults (aged 18-23 years, 18 females) were analyzed. Measures, including average resting state functional connectivity (FC) with respect to 82 Brodmann areas, fractional amplitude of low-frequency fluctuations (FALFF), and a

SUBMITTER: Guo B 

PROVIDER: S-EPMC9299712 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature