Outcomes of bacillus Calmette-Guerin therapy without a maintenance schedule for high-risk non-muscle-invasive bladder cancer in the second transurethral resection era.

ABSTRACT:

Objectives

We examined the outcomes of eight weekly bacillus Calmette-Guérin induction therapy after second transurethral resection, and investigated risk factors for intravesical recurrence or disease progression in high-risk non-muscle-invasive bladder cancer patients.

Methods

This retrospective study included 146 high-risk non-muscle-invasive bladder cancer patients who received eight weekly bacillus Calmette-Guérin instillations without a maintenance schedule between 2000 and 2019. Intravesical recurrence-free and progression-free survival rates were evaluated using the Kaplan-Meier method. The Cox proportional hazards model was used to identify risk factors.

Results

Pathological T staging in the first transurethral resection was pTa in 56 patients (38.4%), pT1 in

SUBMITTER: Kikuchi H 

PROVIDER: S-EPMC9299795 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature