Meropenem pharmacokinetics in critically ill patients with or without burn treated with or without continuous veno-venous haemofiltration.

ABSTRACT:

Introduction

Severe burn injury involves widespread skin and tissue damage leading to systemic inflammation, hypermetabolism and multi-organ failure. The hypermetabolic phase of burn injury has been associated with increased systemic antibiotic clearance; however, critical illness in the absence of burn may also induce similar physiologic changes. Continuous renal replacement therapy (CRRT) is often implemented in critically ill patients and may also affect antibiotic clearance. Although the pharmacokinetics (PK) of meropenem has been described in both the burn and non-burn critically ill populations, direct comparative data is lacking.

Methods

For this study, we evaluated PK parameters of meropenem from 23 critically ill patients, burn or non-burn, treated with or without c

SUBMITTER: Selig DJ 

PROVIDER: S-EPMC9299819 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature