Increased expression of complement components in tuberous sclerosis complex and focal cortical dysplasia type 2B brain lesions.

ABSTRACT:

Objective

Increasing evidence supports the contribution of inflammatory mechanisms to the neurological manifestations of epileptogenic developmental pathologies linked to mammalian target of rapamycin (mTOR) pathway dysregulation (mTORopathies), such as tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD). In this study, we aimed to investigate the expression pattern and cellular distribution of the complement factors C1q and C3 in resected cortical tissue of clinically well-characterized patients with TSC and FCD2B.

Methods

We applied immunohistochemistry in TSC (n = 29) and FCD2B (n = 32) samples and compared them to autopsy and biopsy controls (n = 27). Furthermore, protein expression was observed via Western blot, and for descriptive colocalization studies

SUBMITTER: Gruber VE 

PROVIDER: S-EPMC9299842 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature