Integration of glucose and cardiolipin anabolism confers radiation resistance of HCC.

ABSTRACT:

Background and aims

Poor response to ionizing radiation (IR) due to resistance remains a clinical challenge. Altered metabolism represents a defining characteristic of nearly all types of cancers. However, how radioresistance is linked to metabolic reprogramming remains elusive in hepatocellular carcinoma (HCC).

Approach and results

Baseline radiation responsiveness of different HCC cells were identified and cells with acquired radio-resistance were generated. By performing proteomics, metabolomics, metabolic flux, and other functional studies, we depicted a metabolic phenotype that mediates radiation resistance in HCC, whereby increased glucose flux leads to glucose addiction in radioresistant HCC cells and a corresponding increase in glycerophospholipids biosynthesis to en

SUBMITTER: Fang Y 

PROVIDER: S-EPMC9299851 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature