Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults.

ABSTRACT:

Objective

Omega-6 and omega-3 oxylipins are known to play a role in inflammation and cardiometabolic diseases in preclinical models. The associations between plasma levels of omega-6 and omega-3 polyunsaturated fatty acid-derived oxylipins and body composition and cardiometabolic risk factors in young adults were assessed.

Methods

Body composition, brown adipose tissue, traditional serum cardiometabolic risk factors, inflammatory markers, and a panel of 83 oxylipins were analyzed in 133 young adults (age 22.1[SD 2.2] years, 67% women).

Results

Plasma levels of four omega-6 oxylipins (15-HeTrE, 5-HETE, 14,15-EpETrE, and the oxidative stress-derived 8,12-iso-iPF_2α -VI) correlated positively with adiposity, prevalence of metabolic syndrome, fatty liver index,

SUBMITTER: Jurado-Fasoli L 

PROVIDER: S-EPMC9299871 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature