Trait sensitivity to negative feedback determines the intensity of compulsive alcohol seeking and taking in male rats.

ABSTRACT:

Background

Alcohol use disorder is one of the most common psychiatric disorders, and it is a leading cause of mortality worldwide. It has been demonstrated previously that people with alcohol use disorder are less sensitive to the negative outcomes of their actions and less able to use negative feedback to guide and adjust their ongoing behaviour. However, far less is known about the aberrant processing of negative feedback before the onset of alcohol use disorder. In this study, we investigated the theoretical claim that sensitivity to negative feedback - as a stable and enduring behavioural trait - can predict vulnerability to the development of compulsive alcohol consumption in rats.

Methods

We trained and tested rats in a series of probabilistic reversal learning tests,

SUBMITTER: Cieslik A 

PROVIDER: S-EPMC9299933 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature