Concurrent tau pathologies in frontotemporal lobar degeneration with TDP-43 pathology.

ABSTRACT:

Aims

Accumulating evidence suggests that patients with frontotemporal lobar degeneration (FTLD) can have pathologic accumulation of multiple proteins, including tau and TDP-43. This study aimed to determine the frequency and characteristics of concurrent tau pathology in FTLD with TDP-43 pathology (FTLD-TDP).

Methods

The study included 146 autopsy-confirmed cases of FTLD-TDP and 55 cases of FTLD-TDP with motor neuron disease (FTLD-MND). Sections from the basal forebrain were screened for tau pathology with phosphorylated-tau immunohistochemistry. For cases with tau pathology on the screening section, additional brain sections were studied to establish a diagnosis. Genetic analysis of C9orf72, GRN and MAPT was performed on select cases.

Results

We found 72 cases (36%)

SUBMITTER: Koga S 

PROVIDER: S-EPMC9300011 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature