Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique.

ABSTRACT:

Background

Mozambique is a high-burden tuberculosis (TB) country where TB/HIV co-infection and drug resistant TB (DR-TB) incidence is increasing. Whole genome sequencing (WGS) comprehensively describes the molecular epidemiology of TB, allows prediction of DR-TB phenotypes, lineages strains identification and better understanding of transmission chains.

Objective

To describe genetic diversity of DR-TB Mycobacterium tuberculosis isolated in Beira, Mozambique.

Methods

Descriptive cross-sectional study with 35 M. tuberculosis isolates, resistant to at least one first-line drug on molecular drug-susceptibility tests (DST). Variant identification, DR prediction and phylogenetic analysis provided by WGS, drug-susceptibility pattern compared to line-probe assay (LPA): Genoty

SUBMITTER: Namburete EI 

PROVIDER: S-EPMC9300053 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature