Genome-wide association of individual vulnerability with alcohol-associated liver disease: A Korean genome and epidemiology study.

ABSTRACT:

Background and aims

The quantity of alcohol leading to alcohol-associated liver disease (ALD) varies individually. Genetic backgrounds contributing to the divergence in individual susceptibility to alcohol-induced liver damage have not been elucidated in detail.

Approach and results

Based on the Korean Genome and Epidemiology Study Health Examination (KoGES_HEXA) cohort data, 21,919 participants (40-79 years old) were included and divided into cases and controls based on the ALD diagnostic criteria proposed by the American College of Gastroenterology. Data generated by a genome wide-association study were analyzed using logistic regression to assess the risk of ALD development in nondrinkers, light drinkers, and heavy drinkers. We detected three loci, gamma-glutamyltransfera

SUBMITTER: Kim KY 

PROVIDER: S-EPMC9300105 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature