Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis.

ABSTRACT:

Background and aims

Androgen receptor (AR) has been reported to play an important role in the development and progression of man's prostate cancer. Hepatocellular carcinoma (HCC) is also male-dominant, but the role of AR in HCC remains poorly understood. Mechanistic target of rapamycin complex 1 (mTORC1) also has been reported to be highly activated in HCC. In this study, we aimed to explore the role of AR phosphorylation and its relationship with mTORC1 in hepatocarcinogenesis.

Approach and results

In vitro experiment, we observed that mTORC1 interacts with hepatic AR and phosphorylates it at S96 in response to nutrient and mitogenic stimuli in HCC cells. S96 phosphorylation promotes the stability, nuclear localization, and transcriptional activity of AR, which enhances de

SUBMITTER: Ren QN 

PROVIDER: S-EPMC9300126 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature