Naphthalene Exchange in [Re(η⁶ -napht)₂ ]⁺ with Pharmaceuticals Leads to Highly Functionalized Sandwich Complexes [M(η⁶ -pharm)₂ ]⁺ (M=Re/^99m Tc).

ABSTRACT: Bis-arene sandwich complexes are generally prepared by the Fischer-Hafner reaction, which conditions are incompatible with most O- and N- functional groups. We report a new way for the synthesis of sandwich type complexes [Re(η⁶ -arene)₂ ]⁺ and [Re(η⁶ -arene)(η⁶ -benzene)]⁺ from [Re(η⁶ -napht)₂ ]⁺ and [Re(η⁶ -napht)(η⁶ -benzene)]⁺ , with functionalized arenes and pharmaceuticals. N-methylpyrrolidine (NMP) facilitates the substitution of naphthalene with the incoming arene. A series of fully characterized rhenium sandwich complexes with simple arenes, such as aniline, as well as with active compounds like lidocaine and melatonin are presented. With these rheniu

SUBMITTER: Nadeem Q 

PROVIDER: S-EPMC9300139 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature