Pattern of progression of intrahepatic cholangiocarcinoma: Implications for second-line clinical trials.

ABSTRACT:

Background

Intrahepatic cholangiocarcinoma (iCCA) is the second most frequent liver cancer. The overall survival of iCCA and other biliary tract cancers (BTC) remains poor. Recently, the ABC-06 trial reported the superiority of FOLFOX vs clinical observation as a second-line treatment. Still, the survival benefit was less than expected. We hypothesized that the pattern of progression of iCCA can drive post-progression survival (PPS), similar to hepatocellular carcinoma.

Methods

Multicentre retrospective evaluation of consecutive iCCA patients who progressed after frontline systemic treatment with gemcitabine as monotherapy or in combination with platinum. Radiological assessment of progression was evaluated according to RECIST 1.1. The progression pattern was divided accordi

SUBMITTER: Tovoli F 

PROVIDER: S-EPMC9300150 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature