Misidentified biomedical resources: Journal guidelines are not a quick fix.

ABSTRACT: Biomedical researchers routinely use a variety of biological models and resources, such as cultured cell lines, antibodies and laboratory animals. Unfortunately, these resources are not flawless: cell lines can be misidentified; for antibodies, problems with specificity, lot-to-lot consistency and sensitivity are common; and the reliability of animal models is questioned due to poor translation of animal studies to human clinical trials. In some cases, these problems can render the results of a study meaningless. As a response, some journals have implemented guidelines regarding the use and reporting of cell lines, antibodies and laboratory animals. In our study we use a portfolio of existing and newly created datasets to investigate identification and authentication information of cell li

SUBMITTER: Hepkema WM 

PROVIDER: S-EPMC9300184 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature