A DNA origami rotary ratchet motor.

ABSTRACT: To impart directionality to the motions of a molecular mechanism, one must overcome the random thermal forces that are ubiquitous on such small scales and in liquid solution at ambient temperature. In equilibrium without energy supply, directional motion cannot be sustained without violating the laws of thermodynamics. Under conditions away from thermodynamic equilibrium, directional motion may be achieved within the framework of Brownian ratchets, which are diffusive mechanisms that have broken inversion symmetry^1-5. Ratcheting is thought to underpin the function of many natural biological motors, such as the F₁F₀-ATPase^6-8, and it has been demonstrated experimentally in synthetic microscale systems (for example, to our knowledge, first in ref. 

SUBMITTER: Pumm AK 

PROVIDER: S-EPMC9300469 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature