Association of ATG5 gene polymorphism with Parkinson's disease in a Han Chinese population.

ABSTRACT:

Purpose

There is growing evidence that autophagy-related gene 5 (ATG5) is involved in neural development, neuronal differentiation, and neurodegenerative diseases. The purpose of this study was to investigate the association between ATG5 gene single-nucleotide polymorphisms (SNPs) and Parkinson's disease (PD) in the Han population.

Methods

A case-control study was conducted in 120 PD patients and 100 healthy volunteers. MassArray platform was used to analyze polymorphisms in three different regions of ATG5 gene (rs510432, rs573775 and rs17587319). In the included subjects, 50 PD patients and 50 healthy volunteers were selected, and the plasma ATG5 concentration was detected by enzyme-linked immunosorbent assay (ELISA). The allele and genotype frequencies of SNPs were assesse

SUBMITTER: Han J 

PROVIDER: S-EPMC9300489 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature