Neurophysiological assessment of juvenile parkinsonism due to primary monoamine neurotransmitter disorders.

ABSTRACT: No studies have investigated voluntary movement abnormalities and their neurophysiological correlates in patients with parkinsonism due to inherited primary monoamine neurotransmitter (NT) disorders. Nine NT disorders patients and 16 healthy controls (HCs) were enrolled. Objective measurements of repetitive finger tapping were obtained using a motion analysis system. Primary motor cortex (M1) excitability was assessed by recording the input/output (I/O) curve of motor-evoked potentials (MEP) and using a conditioning test paradigm for short-interval intracortical inhibition (SICI) assessment. M1 plasticity-like mechanisms were indexed according to MEPs amplitude changes after the paired associative stimulation protocol. Patient values were considered abnormal if they were greater or lower t

SUBMITTER: Passaretti M 

PROVIDER: S-EPMC9300560 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature