The NMDA receptor antagonist ketamine impairs and delays context-dependent decision making in the parietal cortex.

ABSTRACT: Flexible decision making is an indispensable ability for humans. A subanesthetic dose of ketamine, an N-methyl-D-aspartate receptor antagonist, impairs this flexibility in a manner that is similar to patients with schizophrenia; however how it affects neural processes related to decision making remains unclear. Here, we report that ketamine administration impairs neural processing related to context-dependent decision making, and delays the onset of decision making. We recorded single unit activity in the lateral intraparietal area (LIP) while monkeys switched between a direction-discrimination task and a depth-discrimination task. Ketamine impaired choice accuracy for incongruent stimuli that required different decisions depending on the task, for the direction-discrimination task. Neural

SUBMITTER: Suda Y 

PROVIDER: S-EPMC9300646 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature