Electrically controlling and optically observing the membrane potential of supported lipid bilayers.

ABSTRACT: Supported lipid bilayers are a well-developed model system for the study of membranes and their associated proteins, such as membrane channels, enzymes, and receptors. These versatile model membranes can be made from various components, ranging from simple synthetic phospholipids to complex mixtures of constituents, mimicking the cell membrane with its relevant physiochemical and molecular phenomena. In addition, the high stability of supported lipid bilayers allows for their study via a wide array of experimental probes. In this work, we describe a platform for supported lipid bilayers that is accessible both electrically and optically, and demonstrate direct optical observation of the transmembrane potential of supported lipid bilayers. We show that the polarization of the supported memb

SUBMITTER: Yudovich S 

PROVIDER: S-EPMC9300657 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature