Selenium Effects on Oxidative Stress-Induced Calcium Signaling Pathways in Parkinson's Disease.

ABSTRACT: Parkinson's disease (PD) is a neurological disorder in which oxidative stress and reactive oxygen species productions are proposed to be involved in its pathogenesis. Despite considerable advancement in Selenium's (Se) molecular biology and metabolism, we do not know much about the cell type-specific pattern of Se distribution in the brain of PD humans and experimental animals. Although, there is plenty of evidence around the role of Se deficiency in PD's pathogenesis impacting lipid peroxidation and reducing glutathione (GSH) and glutathione peroxidase (GPX). It has been suggested that Se has an inducible role in selenium-dependent GPX activity in PD animals and humans. However, calcium as a second messenger regulates the neuron cells' essential activities, but its overloading leads to ce

SUBMITTER: Salaramoli S 

PROVIDER: S-EPMC9300809 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature