Characterization of the Immune Cell Infiltration Landscape in Esophageal Squamous Cell Carcinoma.

ABSTRACT:

Background

Immunotherapy has achieved remarkable efficacy in treating oesophageal squamous cell carcinoma (ESCC). However, this treatment has limited efficacy in some patients. An increasing number of evidence suggested that immune cells within the tumour microenvironment (TME) are strongly related to immunotherapy response and patient prognosis. Thus, the landscape of immune cell infiltration (ICI) in ESCC needs to be mapped.

Methods

In the study, the ICI pattern in 206 cases of ESCC was characterised by two algorithms, namely, CIBERSORT and single-sample gene set enrichment analysis (ssGSEA). The ICI score of each specimen was calculated by principal component analysis (PCA) according to ICI signature genes A (ICISGA) and B (ICISGB). The prognostic difference was evaluated

SUBMITTER: Sui Z 

PROVIDER: S-EPMC9300817 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature