The Roles of Neutrophils Linking Periodontitis and Atherosclerotic Cardiovascular Diseases.

ABSTRACT: Inflammation plays a crucial role in the onset and development of atherosclerosis. Periodontitis is a common chronic disease linked to other chronic inflammatory diseases such as atherosclerotic cardiovascular disease (ASCVD). The mechanistic pathways underlying this association are yet to be fully understood. This critical review aims at discuss the role of neutrophils in mediating the relationship between periodontitis and ASCVD. Systemic inflammation triggered by periodontitis could lead to adaptations in hematopoietic stem and progenitor cells (HSPCs) resulting in trained granulopoiesis in the bone marrow, thereby increasing the production of neutrophils and driving the hyper-responsiveness of these abundant innate-immune cells. These alterations may contribute to the onset, progressio

SUBMITTER: Irwandi RA 

PROVIDER: S-EPMC9300828 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature