Comprehensive Analysis of TRP Channel-Related Genes in Patients With Triple-Negative Breast Cancer for Guiding Prognostic Prediction.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is a special subtype of breast cancer. Transient Receptor Potential (TRP) channel superfamily has emerged as a novel and interesting target in a variety of tumors. However, the association of TRP channel-related genes with TNBC is still unclear.

Methods

The The Cancer Genome Atlas (TCGA)-TNBC and GSE58812 datasets were downloaded from the public database. The differentially expressed TRP channel-related genes (DETGs) were screened by limma package, and mutations of the above genes were analyzed. Subsequently, new molecular subtypes in TNBC-based DETGs were explored by consensus clustering analysis. In addition, Lasso-Cox regression analysis was used to divide it into two robust risk subtypes: high-risk group and low-risk group.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9300844 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature