PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.

ABSTRACT: The effect of cardiovascular dysfunction including orthostatic intolerance and disability on physical exercise is one of the health problems induced by long-term spaceflight astronauts face. As an important part of vascular structure, the vascular endothelium, uniquely sensitive to mechanical force, plays a pivotal role in coordinating vascular functions. Our study found that simulated microgravity induced PINK1-dependent mitophagy in human umbilical vein endothelial cells (HUVECs). Here, we explored the underlying mechanism of mitophagy induction. The ER stress induced by proteostasis failure in HUVECs promoted the Ca²⁺ transfer from ER to mitochondria, resulting in mitochondria Ca²⁺ overload, decreased mitochondrial membrane potential, mitochondria fission, and accu

SUBMITTER: Li C 

PROVIDER: S-EPMC9300855 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature