Investigating the shared genetic architecture of uterine leiomyoma and breast cancer: A genome-wide cross-trait analysis.

ABSTRACT: Little is known regarding the shared genetic architecture or causality underlying the phenotypic association observed for uterine leiomyoma (UL) and breast cancer (BC). Leveraging summary statistics from the hitherto largest genome-wide association study (GWAS) conducted in each trait, we investigated the genetic overlap and causal associations of UL with BC overall, as well as with its subtypes defined by the status of estrogen receptor (ER). We observed a positive genetic correlation between UL and BC overall (r_g = 0.09, p = 6.00 × 10^-3), which was consistent in ER+ subtype (r_g = 0.06, p = 0.01) but not in ER- subtype (r_g = 0.06, p = 0.08). Partitioning the whole genome into 1,703 independent regions, local genetic correlation was identified at

SUBMITTER: Wu X 

PROVIDER: S-EPMC9300879 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature