Efficacy and Safety of Capecitabine for Triple-Negative Breast Cancer: A Meta-Analysis.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with limited treatment options and poor prognosis. Capecitabine, as a novel adjuvant chemotherapy for TNBCs, remains controversial. Therefore, we conducted this meta-analysis to assess the efficacy and safety of capecitabine for early-stage TNBCs combined with neo-/adjuvant chemotherapy.

Methods

We searched Medline, Embase, Web of Science, and Cochrane databases updated on Mar 18, 2022 for relevant RCTs. In all, 11 RCTs with 5,175 patients were included. We used hazard ratios (HRs) and odds ratios (ORs) to assess the differences between disease-free survival (DFS), overall survival (OS), and adverse events.

Results

Our study demonstrated significance differences in both DFS

SUBMITTER: Xun X 

PROVIDER: S-EPMC9300946 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature