Circulating Carnitine Levels and Breast Cancer: A Matched Retrospective Case-Control Study.

ABSTRACT:

Introduction

Epidemiological studies investigating the association between carnitine and breast cancer are scarce.

Materials and methods

This 1:1 age-matched retrospective case-control study identified 991 female breast cancer cases and 991 female controls without breast cancer using pathological testing. We used targeted metabolomics technology to measure 16 types of whole blood carnitine compounds, such as free carnitine (C0) and octadecanoylcarnitine (C18).

Results

The average age for cases and controls was approximately 50 ± 8.7 years. After adjusting for covariates, each standard deviation (SD) increase in malonylcarnitine (C3DC; OR 0.91; 95% CI 0.83-1.00), decenoylcarnitine (C10:1; OR 0.87; 95% CI 0.79-0.96), and decadienoylcarnitine (C10:2; OR 0.90; 95% CI 0.82

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9300951 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature