The Maternal Microbiome Programs the m⁶A Epitranscriptome of the Mouse Fetal Brain and Intestine.

ABSTRACT: The microbiome exerts profound effects on fetal development and health, yet the mechanisms underlying remain elusive. N6-methyladenosine (m⁶A) plays important roles in developmental regulation. Although it has been shown that the microbiome affects the mRNA m⁶A modification of the host, it remains unclear whether the maternal microbiome affects m⁶A epitranscriptome of the fetus so as to impact fetal development. Here, we found that loss of the maternal microbiome altered the expression of m⁶A writers and erasers, as well as the m⁶A methylome of the mouse fetal brain and intestine on embryonic day 18. From the m⁶A profiles, we identified 2,655 and 2,252 m⁶A modifications regulated by the maternal microbiome in the

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC9301011 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature