Sarcopenia and frailty combined increases the risk of mortality in patients with decompensated cirrhosis.

ABSTRACT:

Background

Both sarcopenia and frailty are prevalent in patients with decompensated cirrhosis and associated with negative outcomes. However, few studies investigated the impact of their coexistence on mortality. We aimed to evaluate the role of sarcopenia and frailty on survival in a cohort of hospitalized cirrhotics.

Methods

This was an observational cohort study including 221 patients hospitalized for decompensated events. The cutoff for low skeletal muscle index (SMI) at the third lumbar vertebra level on computed tomography built by our previous work (male: SMI <46.96 cm²/m²; female: SMI <32.46 cm²/m²) was used for the diagnosis of sarcopenia. Individuals with a Frailty Index >0.38 were considered frail. The sample was divided

SUBMITTER: Guo G 

PROVIDER: S-EPMC9301127 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature