TGFβ1 as a Predictive Biomarker for Collateral Formation Within Ischemic Moyamoya Disease.

ABSTRACT:

Objective

Moyamoya disease (MMD) is a unique cerebrovascular occlusive disease characterized by progressive steno-occlusion within the terminal segment of the internal carotid artery. However, good collaterals from an external carotid artery are essential to compensate for the ischemia in moyamoya disease. This study aimed to investigate the transforming growth factor-beta 1 (TGFβ1) in plasma as a potential biomarker for predicting collateral formation in ischemic MMD.

Methods

The transcriptome profile downloaded from Gene Expression Omnibus (GEO) was used to analyze the differential expression of genes between the ischemic MMD and the control groups. We prospectively recruited 23 consecutive patients with ischemic MMD that was diagnosed via digital subtraction angiog

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9301205 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature