Functional MRI Correlates of Carbon Dioxide Chemosensing in Persons With Epilepsy.

ABSTRACT:

Objectives

Sudden unexpected death in epilepsy (SUDEP) is a catastrophic epilepsy outcome for which there are no reliable premortem imaging biomarkers of risk. Percival respiratory depression is seen in monitored SUDEP and near SUDEP cases, and abnormal chemosensing of raised blood carbon dioxide (CO₂) is thought to contribute. Damage to brainstem respiratory control and chemosensing structures has been demonstrated in structural imaging and neuropathological studies of SUDEP. We hypothesized that functional MRI (fMRI) correlates of abnormal chemosensing are detectable in brainstems of persons with epilepsy (PWE) and are different from healthy controls (HC).

Methods

We analyzed fMRI BOLD activation and brain connectivity in 10 PWE and 10 age- and sex-matched HCs d

SUBMITTER: Hampson JP 

PROVIDER: S-EPMC9301231 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature