Propranolol Administration Modulates Neural Activity in the Hippocampal Hilus During Fear Retrieval.

ABSTRACT: Altered fear learning is a strong behavioral component of anxiety disorders such as post-traumatic stress disorder (PTSD). Recent efforts have attempted to combine exposure therapies with drugs that target fear memory retrieval and memory reconsolidation, in order to improve treatment efficacy. The noradrenergic (NA) signaling system is of particular interest, due to its role in regulating the stress response and its involvement in fear and learning processes. Importantly, propranolol (P), a non-selective β-adrenergic antagonist, has shown the potential in decreasing exaggerated fear in both humans and animal models. In a previous study, we utilized an activity-dependent tagging murine model to determine the neural mechanisms by which propranolol attenuates learned fear. We found that prop

SUBMITTER: Leal Santos S 

PROVIDER: S-EPMC9301278 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature