Contribution of Cyclin-dependent Kinase Inhibitor 1B Genotypes to Childhood Leukemia Risk.

ABSTRACT:

Background/aim

Although genetic differences in cell-cycle control genes have been associated with cancer risk, to our knowledge, no report has specifically examined the role of gene variants in childhood acute lymphoblastic leukemia (ALL). Cyclin-dependent kinase inhibitor 1B (CDKN1B; also known as p27/KIP1) is a cell-cycle regulating gene. This study aimed at investigating the association between CDKN1B genotypes and childhood ALL risk.

Materials and methods

In 266 childhood ALL cases and 266 healthy controls, the CDKN1B rs34330 and 2066827 polymorphisms were genotyped, and the association of CDKN1B genotypes with childhood ALL risk were analyzed.

Results

The genotypes of CDKN1B rs34330 and 2066827 were similarly distributed between the control and case groups (p for

SUBMITTER: Pei JS 

PROVIDER: S-EPMC9301415 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature