Association of Obstructive Sleep Apnea With White Matter Integrity and Cognitive Performance Over a 4-Year Period in Middle to Late Adulthood.

ABSTRACT:

Importance

Obstructive sleep apnea (OSA) is associated with cognitive impairment and brain structural alterations, but longitudinal outcomes are understudied.

Objective

To examine the associations of OSA with cognition and white matter (WM) integrity over a 4-year period.

Design, setting, and participants

This prospective cohort study was conducted in a community-based adult population among participants who had both baseline (2011-2014) and 4-year follow-up (2015-2018) polysomnography, diffusion tensor imaging, and cognitive assessment data. Participants with neurological disorders, anomalous findings on brain magnetic resonance imaging, or inadequate quality of the evaluations were excluded. Data were analyzed from March to November 2021.

Exposures

Participan

SUBMITTER: Lee MH 

PROVIDER: S-EPMC9301517 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature