Cervical cell lift: A novel triage method for the spatial mapping and grading of precancerous cervical lesions.

ABSTRACT:

Background

Primary HPV screening, due to its low specificity, requires an additional liquid-based cytology (LBC) triage test. However, even with LBC triage there has been a near doubling in the number of patients referred for colposcopy in recent years, the majority having low-grade disease.

Methods

To counter this, a triage test that generates a spatial map of the cervical surface at a molecular level has been developed which removes the subjectivity associated with LBC by facilitating identification of lesions in their entirety. 50 patients attending colposcopy were recruited to participate in a pilot study to evaluate the test. For each patient, cells were lifted from the cervix onto a membrane (cervical cell lift, CCL) and immunostained with a biomarker of precancerous c

SUBMITTER: Shiraz A 

PROVIDER: S-EPMC9301573 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature