Ontology highlight
ABSTRACT:
SUBMITTER: Zhao T
PROVIDER: S-EPMC9301586 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Zhao Tongtong T Chiang Zachary D ZD Morriss Julia W JW LaFave Lindsay M LM Murray Evan M EM Del Priore Isabella I Meli Kevin K Lareau Caleb A CA Nadaf Naeem M NM Li Jilong J Earl Andrew S AS Macosko Evan Z EZ Jacks Tyler T Buenrostro Jason D JD Chen Fei F
Nature 20211215 7891
The state and behaviour of a cell can be influenced by both genetic and environmental factors. In particular, tumour progression is determined by underlying genetic aberrations<sup>1-4</sup> as well as the makeup of the tumour microenvironment<sup>5,6</sup>. Quantifying the contributions of these factors requires new technologies that can accurately measure the spatial location of genomic sequence together with phenotypic readouts. Here we developed slide-DNA-seq, a method for capturing spatiall ...[more]