Ten-Year Outcomes of Liver Transplant and Downstaging for Hepatocellular Carcinoma.

ABSTRACT:

Importance

National guidelines on transplant selection have adopted successful downstaging to within Milan criteria (MC) as a viable option for the treatment of hepatocellular carcinoma (HCC) before liver transplant (LT). Recurrence of HCC after LT carries a poor prognosis, and treatment modalities remain challenging.

Objective

To establish the 10-year outcomes of patients with HCC after LT in a large, multicenter US study based on individual data; provide robust data on the long-term role of downstaging; and evaluate the association of treatment modalities with postrecurrence survival.

Design, setting, and participants

In this cohort study, a retrospective, multicenter analysis of prospectively collected data was conducted for 2645 adults who had undergone LT for HCC

SUBMITTER: Tabrizian P 

PROVIDER: S-EPMC9301590 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature