Infant gut bacterial community composition and food-related manifestation of atopy in early childhood.

ABSTRACT:

Background

Immunoglobulin E-mediated food allergy (IgE-FA) has emerged as a global public health concern. Immune dysregulation is an underlying mechanism for IgE-FA, caused by "dysbiosis" of the early intestinal microbiota. We investigated the association between infant gut bacterial composition and food-related atopy at age 3-5 years using a well-characterized birth cohort.

Methods

The study definition of IgE-FA to egg, milk, or peanut was based on physician panel retrospective review of clinical and questionnaire data collected from birth through age 3-5 years. Using 16S rRNA sequencing, we profiled the bacterial gut microbiota present in stool specimens collected at 1 and 6 months of age.

Results

Of 447 infants with data for analysis, 44 (9.8%) met physician panel

SUBMITTER: Joseph CL 

PROVIDER: S-EPMC9301652 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature