Size, Shape, and Phase of Nanoscale Uric Acid Particles.

ABSTRACT: Uric acid particles are formed due to hyperuricemia, and previous works have focused on understanding the surface forces, crystallization, and growth of micron- and supermicron-sized particles. However, little to no work has furthered our understanding about uric acid nanonuclei that precipitate during the initial stages of kidney stone formation. In this work, we generate nanosized uric acid particles by evaporating saturated solution droplets of uric acid. Furthermore, we quantify the effects of drying rate on the morphology of uric acid nanonuclei. An aerosol droplet drying method generates uric acid nanoparticles in the size range of 20-200 nm from aqueous droplets (1-6 μm). Results show that uric acid nanonuclei are non-spherical with a shape factor value in the range of 1.1-1.4. The

SUBMITTER: Rastogi D 

PROVIDER: S-EPMC9301715 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature