Dataset Information

The interplay between psychopathological symptoms: transdiagnostic cross-lagged panel network model.

ABSTRACT:

Background

Recent paradigm shifts suggest that psychopathology manifests through dynamic interactions between individual symptoms.

Aims

To investigate the longitudinal relationships between symptoms in a transdiagnostic sample of patients with psychiatric disorders.

Method

A two-wave, cross-lagged panel network model of 15 nodes representing symptoms of depression, (social) anxiety and attenuated psychotic symptoms was estimated, using baseline and 1-year follow-up data of 222 individuals with psychiatric disorders. Centrality indices were calculated to determine important predictors and outcomes.

Results

Our results demonstrated that the strongest relationships in the network were between (a) more suicidal ideation predicting more negative self-view, and (b) autoregressive relationships of social anxiety symptoms positively reinforcing themselves. Negative self-view was the most predictable node in the network as it had the highest 'in-expected influence' centrality, and may be an important transdiagnostic outcome symptom.

Conclusions

The results give insight into longitudinal interactions between symptoms, which interact in ways that do not adhere to broader diagnostic categories. Our results suggest that self-view can also be a transdiagnostic outcome of psychopathology rather than just a predictor, as is normally posited, and may especially have an important relationship with suicidal ideation. Overall, our study demonstrates the dynamic complexity of psychopathology, and further supports the importance of investigating symptom interactions of different psychopathological dimensions over time and across disorders.

SUBMITTER: Chavez-Baldini U

PROVIDER: S-EPMC9301766 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

The interplay between psychopathological symptoms: transdiagnostic cross-lagged panel network model.

Chavez-Baldini UnYoung U Verweij Karin K de Beurs Derek D Bockting Claudi C Lok Anja A Sutterland Arjen L AL van Rooijen Geeske G van Wingen Guido G Denys Damiaan D Vulink Nienke N Nieman Dorien D

BJPsych open 20220627 4

<h4>Background</h4>Recent paradigm shifts suggest that psychopathology manifests through dynamic interactions between individual symptoms.<h4>Aims</h4>To investigate the longitudinal relationships between symptoms in a transdiagnostic sample of patients with psychiatric disorders.<h4>Method</h4>A two-wave, cross-lagged panel network model of 15 nodes representing symptoms of depression, (social) anxiety and attenuated psychotic symptoms was estimated, using baseline and 1-year follow-up data of ...[more]

PMID: 35758630

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Project description:BackgroundReward sensitivity constitutes a potential key mechanism regarding the etiology and maintenance of mental disorders, especially depression. However, due to a lack of longitudinal studies, the temporal dynamics are not clear yet. Although some evidence indicates that reward processing could be a transdiagnostic mechanism of disorders, these observations could be also a product of comorbidity with depression. This study aimed at investigating the temporal dynamics of reward sensitivity and the course of psychopathological symptoms in a longitudinal investigation, while taking a possible mediating role of depression into account.MethodsWe conducted a three-wave longitudinal online survey with a 4-week interval. A total of N = 453 participants filled out all three questionnaires. Reward sensitivity was assessed with the Positive Valence System Scale-21 (PVSS-21), depression with the Patient Health Questionnaire (PHQ-9), eating disorder symptoms with the Eating Disorder Examination-Questionnaire-8 (EDE-Q-8), social anxiety with the Mini-social phobia inventory (Mini-SPIN) and alcohol consumption with the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C). Cross-lagged panels and mediation analyses were calculated using path analyses.ResultsDepressive and eating disorder symptoms predicted reward insensitivity at later points in time. Effects were larger from T2 to T3. A bidirectional relationship concerning social anxiety was found. Higher alcohol consumption predicted higher reward sensitivity. Depression at T2 fully mediated the association between psychopathological symptoms at T1 and reward sensitivity at T3 for social anxiety and eating disorder symptoms.ConclusionsOur findings imply that reduced reward sensitivity seems to be a consequence rather than an antecedent of psychopathological symptoms. Comorbid depression plays a crucial role in other mental disorders regarding observed hyposensitivity towards rewards. Therefore, our results do not support a transdiagnostic notion of reward sensitivity, but they indicate a potential role of reward sensitivity for symptom persistence.Trial registrationThe study was preregistered at the Open Science Framework (OSF) ( https://archive.org/details/osf-registrations-6n3s8-v1 ; registration DOI https://doi.org/10.17605/OSF.IO/6N3S8 ).

Dataset Information

The interplay between psychopathological symptoms: transdiagnostic cross-lagged panel network model.

Background

Aims

Method

Results

Conclusions

Publications

The interplay between psychopathological symptoms: transdiagnostic cross-lagged panel network model.

Similar Datasets

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