Classification of human chronic inflammatory skin disease based on single-cell immune profiling.

ABSTRACT: Inflammatory conditions represent the largest class of chronic skin disease, but the molecular dysregulation underlying many individual cases remains unclear. Single-cell RNA sequencing (scRNA-seq) has increased precision in dissecting the complex mixture of immune and stromal cell perturbations in inflammatory skin disease states. We single-cell-profiled CD45⁺ immune cell transcriptomes from skin samples of 31 patients (7 atopic dermatitis, 8 psoriasis vulgaris, 2 lichen planus (LP), 1 bullous pemphigoid (BP), 6 clinical/histopathologically indeterminate rashes, and 7 healthy controls). Our data revealed active proliferative expansion of the T_reg and Trm components and universal T cell exhaustion in human rashes, with a relative attenuation of antigen-presenting cell

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9301819 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature