Unusually high incidence of polyomavirus JC infection in the higher grade of colorectal cancer tissues in Taiwan.

ABSTRACT:

Introduction

The human JC polyomavirus (JCPyV) has been detected in colorectal cancer (CRC) tissues and is suggested to contribute to CRC tumorigenesis. The rearrangement of the JCPyV regulatory region is supposedly associated with CRC development. The progression of CRC involves the stepwise accumulation of mutations. The large tumor antigen (LT) of JCPyV can trigger uncontrolled cell cycle progression by targeting oncogenes, and tumor suppressor genes, and causing chromosome instability. Few studies have focused on the presence of JCPyV DNA in the higher grade of CRC tissues.

Methods

We collected 95 tissue blocks from samples of stages I, II, III, and IV CRC. Nested PCR targeting the regulatory region of the viral genome was performed to determine the presence of JCPyV DNA

SUBMITTER: Fang CY 

PROVIDER: S-EPMC9301828 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature