Effectiveness of interventions to improve medication adherence in adults with depressive disorders: a meta-analysis.

ABSTRACT:

Background

Non-adherence to medication is a major obstacle in the treatment of depressive disorders. We systematically reviewed the literature to evaluate the effectiveness of interventions aimed at improving adherence to medication among adults with depressive disorders with emphasis on initiation and implementation phase.

Methods

We searched Medline, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, Social Science Citation Index and Science Citation Index for randomized or non-randomized controlled trials up to January 2022. Risk of bias was assessed using the criteria of the Cochrane Collaboration. Meta-analyses, cumulative and meta-regression analyses for adherence were conducted.

Results

Forty-six trials (n = 24,324) were included. P

SUBMITTER: Gonzalez de Leon B 

PROVIDER: S-EPMC9301839 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature