Ascitic Senescent T Cells Are Linked to Chemoresistance in Patients With Advanced High-Grade Serous Ovarian Cancer.

ABSTRACT: Senescent T cells are reported to be increased in patients with cancer and are poor prognostic indicators. However, the distribution of senescent T cells and their correlation with clinical features in high-grade serous ovarian cancer (HGSOC) is unknown. We detected the percentage of senescent T cells in the peripheral blood and ascites of patients with advanced HGSOC (n = 86) at diagnosis by flow cytometry. Compared with healthy donors, patients with HGSOC exhibited an accumulation of CD28^-CD57⁺ (Tsen) CD8⁺ T cells in the peripheral blood and ascites. The frequency of Tsen CD8⁺ T cells in the peripheral blood was positively correlated with age and pretreatment serum CA125 and increased in patients with large volume ascites, whereas the frequency

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9301961 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature