Interferon-γ Release Assays in Children <15 Years of Age.

ABSTRACT:

Objectives

The tuberculin skin test (TST) has been preferred for screening young children for latent tuberculosis infection (LTBI) because of concerns that interferon-γ release assays (IGRAs) may be less sensitive in this high-risk population. In this study, we compared the predictive value of IGRAs to the TST for progression to tuberculosis disease in children, including those <5 years old.

Methods

Children <15 years old at risk for LTBI or progression to disease were tested with TST, QuantiFERON-TB Gold In-Tube test (QFT-GIT), and T-SPOT.TB test (T-SPOT) and followed actively for 2 years, then with registry matches, to identify incident disease.

Results

Of 3593 children enrolled September 2012 to April 2016, 92% were born outside the United States; 25% were <

SUBMITTER: Ahmed A 

PROVIDER: S-EPMC9301964 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature