Protease Activity Analysis: A Toolkit for Analyzing Enzyme Activity Data.

ABSTRACT: Analyzing the activity of proteases and their substrates is critical to defining the biological functions of these enzymes and to designing new diagnostics and therapeutics that target protease dysregulation in disease. While a wide range of databases and algorithms have been created to better predict protease cleavage sites, there is a dearth of computational tools to automate analysis of in vitro and in vivo protease assays. This necessitates individual researchers to develop their own analytical pipelines, resulting in a lack of standardization across the field. To facilitate protease research, here we present Protease Activity Analysis (PAA), a toolkit for the preprocessing, visualization, machine learning analysis, and querying of protease activity data sets. PAA leverag

SUBMITTER: Soleimany AP 

PROVIDER: S-EPMC9301967 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature